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KMID : 0978920040050040433
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Korean Journal of Clinical Geriatrics
2004 Volume.5 No. 4 p.433 ~ p.441
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Effect of Glucomannan on Glucose and Lipid Metabolism in Elderly Type II Diabetic Subjects
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Kim Chul-Sik
Cha Bong-Soo
Ahn Chul-Woo
Kim Kyung-Rae
Lim Sung-Kil
Lee Hyun-Chul
Nam Ji-Sun
Cho Min-Ho
Park Jin-A
Kim Dol-Mi
Nam Joo-Young
Park Jong-Suk
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Abstract
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Background: Glucomannan is known to be effective in reducing glucose and lipid absorption from small intestine. In this study, we tried to investigate the relationship between glucomannan and glucose, lipid profile, and insulin resistance in the elderly type 2 diabetes patients.
Method: We have taken 76 type 2 diabetes patinets with hypercholesterolemia, aged over 60 years old, who have visited our endocrine clinic of Yonsei University of Medical College and categorized them into two groups. The experimental group, which consisted of 39 subjects, received daily glucomannan, while the control group, which consisted of 37 patients, received daily placebo for 8 weeks. We have measured fasting glucose, 2hr post-prandial glucose at 0, 4, 8 weeks and HbA1C, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, insulin, c-peptide levels at 0, 8 weeks, and calculated HOMA score in order to determine insulin resistance.
Results: The following results were obtained. 1) 2hr postprandial glucose level was significantly reduced after taking glucomannan for 4 and 8 weeks, and fasting glucose level declined after taking glucomannan for 8 weeks. 2) Serum total cholesterol, triglyceride, LDL-cholesterol levels were significantly lowered after treatment. Serum HDL-cholesterol level had a tendency to increase in the experimental group, but was not statistically significant. 3) HbA1C was significantly decreased after taking glucomannan for 8 weeks. 4) HOMA-IR was reduced at 8 weeks, and HOMA-β showed a significant increase at 8 weeks. 5) Glucomannan did not have adverse effects on CBC, liver function, renal function, and
electrolyte levels.
Conclusion: The above study results demonstrate that glucomannan is effective in improving glucose and lipid metabolism in elderly type 2 diabetes patients. Glucomannan enhances insulin resistance by lowering postprandial gluocse level and stimulating insulin secretion.
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KEYWORD
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Glucomannan, Elderly, Type 2 diabetes
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